Chemical and Cancer Biology Branch
Institute for Basic Science - Center for Genomic Integrity
2023
van den Heuvel D., Kim M, Witkamp M, Lambregtse F, Kim HS, Kan F, Apelt K, Kragten A, Gonzalez-Pietro, R, Vertegal ACO, Yeo JE, Kim BG, van Doorn R, Schärer OD*, Luijsterburg MS* (2023) A disease associated XPA allele interferes with TFIIH binding and primarily affect the transcription-coupled sub-pathway of nucleotide excision repair. Proc Natl Acad Sci USA, 120, e2208860120. *Joint corresponding authors
Aruna J., Kim HS, Schärer OD, Neelam S, Williamson E, Srinivasan G, Kong K, Arya S, Misra, A, Dutta A, Gupta Y, Walter C, Philips L, Burma S, Satya N, Sung P, Nickoloff J, Hromas R (2023) EEPD1 Promotes Repair of Oxidatively-Stressed Replication Forks. NAR Cancer 5, zcac044
2022
Groehler AS, Maratova A, Dao NM, Makhmut A, Schärer OD (2022) Development of Comprehensive Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry Assays to Quantitate Cisplatin-Induced DNA-DNA Cross-Links. bioRvix 2022.09.28.509855v1
Chung HJ, Lee JR, Kim S, Park K, Kim TM, Kim MJ, Jung EY, Kim S, Lee EA, Ra JS, Hwang S, Lee JY, Schärer OD, Kim YH, Myung K, Kim HT (2023) ZNF212 participates in interstrand DNA crosslink repair through direct interaction with TRAIP. Nucleic Acids Res 51, 631-649.
Kim M, Kim HS, D’Souza A, Gallagher K, Jeong E, Topolska-Wos A, Ogorodnik Le Meur K, Tsai CL, Tsai MS, Kee M, Tainer JA, Yeo JE, Chazin WJ, Schärer OD (2022) Two Interaction Surfaces Between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair. Proc Natl Acad Sci USA 119, e2207408119.
Blessing C, Apelt K, van den Heuvel D, Gonzalez-Leal, Rother MB, van der Woude M, Tyrsett T, Conzalez-Pietro R, Yifrach A, Parnas A, Shah, RG, Boer D, Kragten A, Kim HS, Vertegaal ACO, Schärer OD, Shah GM, Adar S, Lans H, van Attikum H, Ladurner AG, Luijsterburg MS (2022) XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze robust global genome DNA damage repair. Nat Commun 13, 4762.
Tan Y, You C, Park J, Kim HS, Guo S, Schärer OD, Wang Y (2022) Transcriptional Perturbations of 2,6-diaminopurine and 2-aminopurine. ACS Chem Biol 17, 1672-1676.
Yue Z, Wu F, Guo F, Park J, Wang J, Liyun Z, Lao D, Li W, Schärer OD, Lei X (2022) Polycarcin V induces DNA damage response and enables the profiling of DNA-binding proteins. Nat Sci Rev 9, nwac046.
van Toorn M, Turkyilmaz Y, Han S, Zhou D, Kim HS, Salas-Armenteros I, Kim M, Akita M, Wienholz F, Raams A, Ryu EJ, Kang S, Theil AF, Bezstarosti K, Tresini M, Giglia-Mari G, Demmers JA, Schärer OD, Choi JH, Vermeulen W, Marteijn JA. (2022) Active DNA damage eviction by HLTF stimulates nucleotide excision repair. Mol Cell 82, 1343-1358.
Aloisi CMN, Escher NA, Kim HS, Geisen S, Fontana G, Yeo JE, Schärer OD*, Sturla SJ* (2022) A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation. DNA Repair 110, 103262. *Joint corresponding authors
2021
Apelt K, Lans H, Schärer OD, Luijsterburg MS (2021) Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes. Cell Mol Life Sci, 78, 7925-7942.
von Werdt A, Brandt L, Schärer OD, Rubin MA (2021) PARP Inhibition in Prostate Cancer with Homologous Recombination Repair Alterations. JCO Precis Oncol, 5, 1639-1649.
Cheun YK, Groehler AS 4th, Schärer OD (2021) New Synthetic Analogs of Nitrogen Mustard DNA Interstrand Crosslinks and Their Use to study Bypass DNA polymerases. Chem Res Tox 34, 1790-1799.
Tsao N, Schärer OD*, Mosammaparast N* (2021) The complexity and regulation of the repair of alkylation damage to nucleic acids. Crit Rev Biochem Mol Biol, doi:10.1080/10409238.2020.1869173
Apelt K, White SM, Kim HS, Yeo JE, Kragten A, Wondergem AP, Rooimans MA, Gonzalez-Prieto R, Wiegant WW, Lunke S, Flanagan D, Pantaleo S, Quinlan C, Hardikar W, van Attikum H, Vertegaal CO, Wilson BT, Wolthuis RMF, Schärer OD, Luijsterburg MS (2021) ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients. J Exp Med 218 , e20200622
2020
Tsutakawa SE, Tsai CL, Yan C, Bralić A, Chazin WJ, Hamdan SM, Schärer OD, Ivanov I, Tainer JA (2020) Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair. DNA Repair, 96, 102972.
Rageul J, Park J, Zeng PP, Lee EA, Yang JY, Hwang SY, Lo N, Westheimer A, Schärer OD, Yeo JE*, Kim HJ* (2020) SDE integrates into the TIMELESS-TIPIN Complex to Protect Stalled Replication Forks. Nature Communications, 11, 5495
Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride KM, Murnane JP, Bhak J, Lee S, Wood RD, Takata KI (2020) Defining the mutation signatures of DNA polymerase θ in cancer genomes, NAR Cancer, 2, zcaa017
Bezalel-Buch R, Cheun YK, Roy U, Schärer OD, Burgers P (2020) Bypass of DNA interstrand crosslinks by a Rev1-DNA Polymerase Z complex. Nucleic Acids Res, 48, 8461-8473
Son K, Schärer OD (2020) Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation Cell 180, 1039-1041
Jeong E, Lee SK, Kim HS, Yang J, Shin J, Kim J, Schärer OD, Kim Y, Yeo JE, Kim HM, Cho Y (2020) Structural basis of the Fanconi anemia-associated mutations within the FANCA and FANCG complex Nucleic Acids Res, 48, 3328-3342
Topolska-Woś AM, Sugitani N, Cordoba JJ, Le Meur KV, Le Meur RA, Kim HS, Yeo JE, Rosenberg D, Hammel M, Schärer OD, Chazin WJ (2020) Interaction with RPA orients XPA in NER complexes. Nucleic Acids Res, 48, 2173-2188
Raghunandan M, Yeo JE, Walter R, Saito K, Harvey AJ, Ittershagen S, Lee EA, Yan J, Hoatlin ME, Bielinsky AK, Hendrickson EA, Schärer OD, Sobeck A (2020) Functional crosstalk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Hum Mol Genet, 29, 1083-1095.
2019
Srinivasan G, Williamson EA, Kong K, Jaiswal AS, Huang G, Kim HS, Schärer O, Zhao W, Burma S, Sung P, Hromas R (2019) MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers. Proc Natl Acad Sci USA, 35, 17438-17443
Cheon NY, Kim HS, Yeo JE, Schärer OD, Lee JY (2019) Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B. Nucleic Acids Res, 47, 8337-8437
Liu X, Jiang Y, Takata K, Nowak B, Liu C, Wood RD, Hittelman WN, Plunkett W (2019) CNDAC-induced DNA double strand breaks cause aberrant mitosis prior to cell death. Mol Cancer Ther., 18, 2283-2295
2018
Mu H, Geacintov NE, Broyde S, Yeo JE, Schärer OD (2018) Molecular Basis for Damage Recognition and Verification by XPC-RAD23B and TFIIH in Nucleotide Excision Repair . DNA Repair, 71, 33-42
Jin HS, Roy U, Lee G, Schärer OD, Cho Y (2018) Structural Mechanism of DNA Interstrand Cross-Link Unhooking by the Bacterial FAN1 Nuclease. J Biol Chem 293, 6482-6406.
2017
Cheun Y, Schärer OD (2017) Studying DNA Repair Pathways Using Site-Specifically Modified Oligonucleotides (Invited Newsletter Review), Glen Rep 29.1, 6-9.
Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J (2017) Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Rep 5, 1375-1385
Thompson E, Yeo JE; Lee EA; Kan Y, Raghunandan M, Wiek C, Hanenberg H, Schärer, OD, Hendrickson EA, Sobeck A (2017) FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Nucleic Acids Res, 45, 11837-11857
Schärer, O.D. (2017) ERCC1-XPF endonuclease – positioned to cut (News and Views Article). EMBO J, 36, 1993-1995
Castaño A, Roy U, Schärer OD (2017) Preparation of Stable Nitrogen Mustard DNA Inter Strand Crosslink Analogs for Biochemical and Cell Biological Studies. Methods Enzymol, 591, 415-431
Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Schärer OD, and McVey M (2017) Drosophila DNA Polymerase Theta Utilizes both Helicase-Like and Polymerase Domains during Microhomology-Mediated End Joining and Interstrand Crosslink Repair. PLoS Genetics, 13, e1006813
Woodrick JA, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, Bai Y, Khatakar P, Erzikan HV, Sami, F, Su Y, Schärer OD, Sharma S, Roy R (2017) A new sub-pathway of long-patch base excision repair involving 5' gap formation. EMBO J, 36, 1605-1622.
Pande P, Ji S, Mukherjee S, Schärer OD, Tretyakova NY, Basu AK (2017) Mutagenicity of a model DNA-peptide crosslink in human cells: Roles of translesion synthesis polymerases. Chem Res Tox, 30, 669-677.