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2022

Tan Y, You C, Park J, Kim HS, Guo S, Schärer OD, Wang Y (2022) Transcriptional Perturbations of 2,6-diaminopurine and 2-aminopurine. ACS Chem Biol, published on June 15, 2022, as doi.org/10/1021/acschembio.2c00369.

Kim M, Kim HS, D’Souza A, Gallagher K, Jeong E, Topolska-Wos A, Ogorodnik Le Meur K, Tsai CL, Tsai MS, Kee M, Tainer JA, Yeo JE, Chazin WJ, Schärer OD (2022), Two Interaction Surfaces Between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair, bioRvix, doi.org10.1101/2022.03.01.482439

Yue Z, Wu F, Guo F, Park J, Wang J, Liyun Z, Lao D, Li W, Schärer OD, Lei X (2022) Polycarcin V induces DNA damage response and enables the profiling of DNA-binding proteins Nat Sci Revdoi.org/10/1093/nr/nwac046.

van Toorn M, Turkyilmaz Y, Han S, Zhou D, Kim HS, Salas-Armenteros I, Kim M, Akita M, Wienholz F, Raams A, Ryu EJ, Kang S, Theil AF, Bezstarosti K, Tresini M, Giglia-Mari G, Demmers JA, Schärer OD, Choi JH, Vermeulen W, Marteijn JA (2022) Active DNA damage eviction by HLTF stimulates nucleotide excision repair. Mol Cell, 82, 1343-1358.

Aloisi CMN, Escher NA, Kim HS, Geisen S, Fontana G, Yeo JE, Schärer OD*, Sturla SJ* (2022) A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation. DNA Repair 110, 103262

2021 

Apelt K, Lans H, Schärer OD, Luijsterburg MS (2021) Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes. Cell Mol Life Sci, 78, 7925-7942.

 

von Werdt A, Brandt L, Schärer OD, Rubin MA (2021) PARP Inhibition in Prostate Cancer with Homologous Recombination Repair Alterations. JCO Precis Oncol, 5, 1639-1649.

 

Cheun YK, Groehler AS 4th, Schärer OD (2021) New Synthetic Analogs of Nitrogen Mustard DNA Interstrand Crosslinks and Their Use to study Bypass DNA polymerases. Chem Res Tox 34, 1790-1799.

Tsao N, Schärer OD*, Mosammaparast N* (2021) The complexity and regulation of the repair of alkylation damage to nucleic acids. Crit Rev Biochem Mol Biol, doi:10.1080/10409238.2020.1869173
 

Apelt K, White SM, Kim HS, Yeo JE, Kragten A, Wondergem AP, Rooimans MA, Gonzalez-Prieto R, Wiegant WW, Lunke S, Flanagan D, Pantaleo S, Quinlan C, Hardikar W, van Attikum H, Vertegaal CO, Wilson BT, Wolthuis RMF, Schärer OD, Luijsterburg MS (2021) ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients. J Exp Med 218 , e20200622

2020

Tsutakawa SE, Tsai CL, Yan C, Bralić A, Chazin WJ, Hamdan SM, Schärer OD, Ivanov I, Tainer JA (2020) Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair. DNA Repair, 96, 102972.

 

Rageul J, Park J, Zeng PP, Lee EA, Yang JY, Hwang SY, Lo N, Westheimer A, Schärer OD, Yeo JE*, Kim HJ* (2020) SDE integrates into the TIMELESS-TIPIN Complex to Protect Stalled Replication Forks. Nature Communications, 11, 5495 

Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride KM, Murnane JP, Bhak J, Lee S, Wood RD, Takata KI (2020) Defining the mutation signatures of DNA polymerase θ in cancer genomes, NAR Cancer, 2, zcaa017

Bezalel-Buch R, Cheun YK, Roy U, Schärer OD, Burgers P (2020) Bypass of DNA interstrand crosslinks by a Rev1-DNA Polymerase Z complex. Nucleic Acids Res, 48, 8461-8473

Son K, Schärer OD (2020) Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation Cell 180, 1039-1041

 

Jeong E, Lee SK, Kim HS, Yang J, Shin J, Kim J, Schärer OD, Kim Y, Yeo JE, Kim HM, Cho Y (2020) Structural basis of the Fanconi anemia-associated mutations within the FANCA and FANCG complex Nucleic Acids Res, 48, 3328-3342

Topolska-Woś AM, Sugitani N, Cordoba JJ, Le Meur KV, Le Meur RA, Kim HS, Yeo JE, Rosenberg D, Hammel M, Schärer OD, Chazin WJ (2020) Interaction with RPA orients XPA in NER complexes. Nucleic Acids Res, 48, 2173-2188

Raghunandan M, Yeo JE, Walter R, Saito K, Harvey AJ, Ittershagen S, Lee EA, Yan J, Hoatlin ME, Bielinsky AK, Hendrickson EA, Schärer OD, Sobeck A (2020) Functional crosstalk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Hum Mol Genet, 29, 1083-1095.

2019

 

Srinivasan G, Williamson EA, Kong K, Jaiswal AS, Huang G, Kim HS, Schärer O, Zhao W, Burma S, Sung P, Hromas R (2019) MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers. Proc Natl Acad Sci USA, 35, 17438-17443

Cheon NY, Kim HS, Yeo JE, Schärer OD, Lee JY (2019) Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B. Nucleic Acids Res, 47, 8337-8437

Liu X, Jiang Y, Takata K, Nowak B, Liu C, Wood RD, Hittelman WN, Plunkett W (2019) CNDAC-induced DNA double strand breaks cause aberrant mitosis prior to cell death. Mol Cancer Ther., 18, 2283-2295

2018

Mu H, Geacintov NE, Broyde S, Yeo JE, Schärer OD (2018) Molecular Basis for Damage Recognition and Verification by XPC-RAD23B and TFIIH in Nucleotide Excision Repair . DNA Repair, 71, 33-42

Jin HS, Roy U, Lee G, Schärer OD, Cho Y (2018) Structural Mechanism of DNA Interstrand Cross-Link Unhooking by the Bacterial FAN1 Nuclease. J Biol Chem 293, 6482-6406.

2017

 

Cheun Y, Schärer OD (2017) Studying DNA Repair Pathways Using Site-Specifically Modified Oligonucleotides (Invited Newsletter Review), Glen Rep 29.1, 6-9.

Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J (2017) Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Rep 5, 1375-1385

Thompson E, Yeo JE; Lee EA; Kan Y, Raghunandan M, Wiek C, Hanenberg H, Schärer, OD, Hendrickson EA, Sobeck A (2017) FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Nucleic Acids Res, 45, 11837-11857

Schärer, O.D. (2017) ERCC1-XPF endonuclease – positioned to cut (News and Views Article). EMBO J, 36, 1993-1995

Castaño A, Roy U, Schärer OD (2017) Preparation of Stable Nitrogen Mustard DNA Inter Strand Crosslink Analogs for Biochemical and Cell Biological Studies. Methods Enzymol, 591, 415-431

Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Schärer OD, and McVey M (2017) Drosophila DNA Polymerase Theta Utilizes both Helicase-Like and Polymerase Domains during Microhomology-Mediated End Joining and Interstrand Crosslink Repair. PLoS Genetics, 13, e1006813

Woodrick JA, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, Bai Y, Khatakar P, Erzikan HV, Sami, F, Su Y, Schärer OD, Sharma S, Roy R (2017) A new sub-pathway of long-patch base excision repair involving 5' gap formation. EMBO J, 36, 1605-1622.

Pande P, Ji S, Mukherjee S, Schärer OD, Tretyakova NY, Basu AK (2017) Mutagenicity of a model DNA-peptide crosslink in human cells: Roles of translesion synthesis polymerases. Chem Res Tox, 30, 669-677.